I feel like it needs to be something other than a two-hander to really work, otherwise audiences are just going to wish they were watching Mulder and Scully.
I long had an idea for an X-Files spinoff that was like an anthology where each season followed up on and expanded on a bunch of classic MotW episodes. Hell or just do a bunch of whole series inspired by MotW episodes. You'd have material to last decades. I'd rather them leave the Mythos stuff alone for now.
Restarted my intended watch of the whole series yesterday; half way through season 1. Just finished the one with the psychic death row dude who helped Scully find the missing teens.